中西医药发展

基于MOFs的POMs负载与传输机理及其生物医药应用研究

何 丹凤

琼台师范学院理学院

张 晓琳

琼台师范学院理学院

姜 丹

琼台师范学院理学院

周 付江

琼台师范学院理学院

张 新星

琼台师范学院理学院

朱 为菊

琼台师范学院理学院

许 环军

琼台师范学院理学院

DOI: https://doi.org/10.59429/zxyy.v3i4.15124

Keywords: 金属有机框架（MOFS）；多金属氧酸盐（POMS）；刺激响应释放；传输机理

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Abstract

多金属氧酸盐（Polyoxometalates, POMs）是一类由前过渡金属离子通过氧原子桥连形成的纳米级阴离子簇合 物，具有抗肿瘤、抗病毒、抗菌等多重生物活性。然而，游离态 POMs 水溶性过强、缺乏靶向性、生物利用度低等 缺陷严重制约其临床应用。金属有机框架（Metal-Organic Frameworks, MOFs）凭借其可调孔径、高比表面积、表面 可功能化及刺激响应性降解等特性，为 POMs 的负载与可控释放提供了理想平台。本文系统研究 POMs@MOFs 复合 体系的构建策略，包括原位封装法、后合成浸渍法、缺陷工程锚定法、静电自组装法及其界面作用机制；重点梳理 pH 响应、谷胱甘肽（GSH）响应等肿瘤微环境相关刺激下的释放行为与动力学规律；详细评述该复合体系在肿瘤光 热 / 化学动力学协同治疗、抗菌等生物医学领域的研究进展；分析当前面临的体内稳定性、生物相容性及靶向精准 性等关键挑战；并对多功能协同载体设计、多刺激响应系统构建等发展方向进行展望。

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References

[1] Recent advances in porous nanomaterials-based drug delivery system[J]. Journal of Nanobiotechnology, 2022, 20:277.

[2] Current status of controlled onco-therapies based on metal organic frameworks[J]. PMC, 2024.

[3] Anticancer, antimicrobial and biomedical features of polyoxometalate as advanced materials: A review study[J]. 2022.

[4] Polyoxometalate-based materials in therapeutic and biomedical applications: current status and perspective[J]. Dalton Transactions, 2025.

[5] Advancing biomedical applications of polyoxometalate-based metal-organic frameworks: from design to therapeutic potential[J]. Inorganic Chemistry Frontiers,2024.

[6] GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy[J].Inorganic Chemistry Frontiers, 2024, 11: 4439-4448.

[7] An injectable dual-layer chitosan-alginate nano-hydrogel incorporated Cu(I)-isopolymolybdate-based metal-organic framework tailored for three-in-one anti-cancer

nanotherapy[J]. International Journal of Biological Macromolecules,2024, 282(Pt 6): 137381.

[8] H₂O₂ Self-Supplying CaO₂/POM@MOF Bimodal Nanogeneration Materials for Photothermal and Chemodynamic Synergistic Antimicrobials[J]. Applied Organometallic Chemistry,2024.

[9] Metal-organic frameworks for precision delivery of multi-component traditional Chinese medicines: Integrating stimuli-responsive mechanisms, chromatographic quantitation,and TCM theory-driven innovation[J]. 2026.

[10] Bridging traditional Chinese medicine theory with advanced MOFs delivery for synergistic drug-resistant infected-chronic wound therapy[J]. Materials Today Bio, 2026, 37:102861.