中西医药发展

CEMIP调控透明质酸代谢与疾病病理的研究进展

黄 宇

重庆科技大学

许 成

重庆科技大学

蒋 海兵

重庆科技大学

张 茜烽

重庆科技大学

黄 璐

重庆邮电大学

张 涛

重庆科技大学

DOI: https://doi.org/10.59429/zxyy.v3i4.15134

Keywords: CEMIP；透明质酸；细胞外基质；上皮-间充质转化；炎症；肿瘤

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Abstract

细胞迁移诱导蛋白（CEMIP，亦称 KIAA1199/HYBID）是一类参与透明质酸（HA）降解的关键蛋白。HA 作 为细胞外基质中含量最丰富的糖胺聚糖，对维持组织正常结构与功能不可或缺。自 CEMIP 在非综合征性耳聋患者中 被首次鉴定以来，大量研究表明该蛋白在肿瘤、关节炎、动脉粥样硬化和特发性肺纤维化等多种疾病中发挥重要作 用，但其分子功能及病理条件下的调控机制尚未完全阐明。本文系统梳理了 CEMIP 的结构特征、HA 降解活性、组 织特异性表达、多层次调控网络及其在肿瘤、炎症性疾病及衰老相关疾病中的病理作用，并展望其作为潜在治疗靶 点的前景，以期为后续研究提供参考。

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