Metabolite-conditioned sequential multi-strain probiotic platform for weight management: Bacillus coagulans-centered ecological relay, evidence context, and translational positioning
Anas Ziraoui
European Life Science Research Association
Lucie Garnier
European Life Science Research Association
Lea Hartmann
European Life Science Research Association
DOI: https://doi.org/10.59429/pest.v8i2.14493
Keywords: bacillus coagulans; bifidobacterium animalis; lactobacillus plantarum; weight management; sequential colonization; probiotic platform
Abstract
Background: Weight-management probiotics often fail because viability declines during storage and strains are blended without ecological coordination. Methods: This article condenses the reported dataset for a Bacillus coagulans-centered sequential platform combining B. coagulans spores, Lactobacillus plantarum, Bifidobacterium animalis, and a cell-free Bacillus metabolite filtrate. Results: Across the reported examples, 6-month retention remained about 85%, peak distal-colon B. animalis abundance reached 9.1-9.2 × 106 CFU/g, and 8-week body-weight reduction reached up to 15.7% in high-fat-diet mice, versus 52.0%, 2.1 × 106 CFU/g, and 4.2% in the direct-mix comparator. Conclusions: The platform’s main strength is the coupling of metabolite pre-conditioning, staged intestinal relay, and phenotype-linked efficacy.
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