A multi-pathway heme iron–glycine chelated iron system with a natural vitamin C matrix for iron repletion
Aisha Noor
World Food Supplement Associatio
Jabar Yassine
World Food Supplement Associatio
Gregg L.Semenza
World Food Supplement Associatio
DOI: https://doi.org/10.59429/pest.v8i2.14501
Keywords: heme iron; glycine chelated iron; ferrous gluconate; ferrous lactate; camu camu; acerola; iron deficiency anemia; HIF; erythropoiesis; oxygen sensing
Abstract
I examine an oral iron formulation that combines heme iron, glycine chelated iron, ferrous gluconate, ferrous lactate, camu camu extract, and acerola cherry extract within one coordinated system. The design is unusual because it integrates heme-associated uptake, chelation-associated transport, and rapid ionic contribution while preserving a natural vitamin C-rich matrix. In the disclosed dataset, the lead embodiment retained 93.25% vitamin C at 6 months, reached 98.26% cumulative ferrous dissolution at 60 minutes, achieved 38.72±2.15% rat intestinal iron absorption, and restored hemoglobin, hematocrit, serum iron, and ferritin more strongly than three comparators. I interpret these findings through the oxygensensing framework associated with Gregg L. Semenza, because iron repletion ultimately serves oxygen delivery, erythropoiesis, and iron homeostasis as an integrated system [1-12].
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