先进急诊医学

重症急性胰腺炎肝损伤相关机制的研究进展

王 荣

右江民族医学院研究生院

尹 毅霞

右江民族医学院临床医学院

郭 若琳

右江民族医学院研究生院

罗 永

右江民族医学院研究生院

DOI: https://doi.org/10.59429/xjjz.v6i3.7293

Keywords: 重症急性胰腺炎；肝损伤；炎症反应；发病机制

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Abstract

重症急性胰腺炎（severe acute pancreatitis，SAP）是临床上常见的消化系统急性重症，具有起病急、发展迅速、 死亡率高的特点，目前尚未有特效疗法，全身炎症反应综合征（systemic inflammatory response syndrome，SIRS）引 发的多器官功能衰竭为 SAP 患者的主要的死亡原因，肝脏作为与胰腺关系密切的器官也是 SAP 主要受损器官之一， 其受损程度可反映 SAP 患者的预后。肝脏损伤导致机体处理炎症因子及毒素的能力下降，进一步加重患者病情。 SAP 肝损伤的机制尚未完全阐明，本综述将系统地阐述 SAP 肝损伤可能的机制，为 SAP 合并多脏器损伤提供科学的 诊疗思路。

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