先进急诊医学

OTUB2 在多种肿瘤中的研究进展

曾 志远

承德医学院附属医院

张 志民

承德医学院附属医院

DOI: https://doi.org/10.59429/xjjz.v7i1.9409

Keywords: OTUB2；乳腺癌；宫颈癌；结直肠癌；胃癌

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Abstract

泛素化和去泛素化酶的失调是各种癌症发生、发展的共同特征。OTUB2 是一种重要的去泛素化分子，通 过蛋白去泛素化修饰调节生物体内许多重要的细胞过程。例如，相关蛋白质的降解和定位、细胞信号通路的调节。 OTUB2 在乳腺癌、宫颈癌、结直肠癌、胃癌、甲状腺癌等多种肿瘤中异常高表达，在肿瘤的发生、发展中起着重要 作用。论文就 OTUB2 在多种癌症中的研究进展进行综述。

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References

[1] Altun M, Walter T S, Kramer H B, et al. The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages[J]. PLoS One,2015,10(1):e0115344.

[2] Li, Jun. The emerging role of OTUB2 in diseases: from cell signaling pathway to physiological function[J]. Frontiers in Cell and Developmental Biology,2022(10):820781.

[3] Weigelt B, Geyer F C, Reis-Filho J S. Histological types of breast cancer: how special are they?[J]. Molecular oncology, 2010,4(3):192-208.

[4] Deng Y, Li J, He Y, et al. The deubiquitinating enzymes-related signature predicts the prognosis and immunotherapy response in breast cancer[J]. Aging (Albany NY),2024,16(15):11553.

[5] Burmeister C A, Khan S F, Schäfer G, et al. Cervical cancer therapies: Current challenges and future perspectives[J]. Tumour Virus Research,2022(13):200238.

[6] Song Y, Wu Q. RBM15 m6A modification‐mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling[J]. Environmental Toxicology,2023,38(9):2155-2164.

[7] Xiao J, Wang L, Zhuang Y, et al. The deubiquitinase OTUB2 promotes cervical cancer growth through stabilizing FOXM1[J]. American Journal of Translational Research,2024,16(1):75.

[8] Yu S, Zang W, Qiu Y, et al. Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis[J]. Oncogene,2022,41(1):46-56.

[9] Xu X, Wu G, Han K, et al. Inhibition of OTUB2 suppresses colorectal cancer cell growth by regulating β-Catenin signaling[J]. American Journal of Cancer Research,2023,13(11):5382.

[10] Joshi S S, Badgwell B D. Current treatment and recent progress in gastric cancer[J]. CA: a cancer journal for clinicians,2021,71(3):264-279.

[11] Ouyang S, Zeng Z, Liu Z, et al. OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer[J]. Cell Death Discovery,2022,8(1):45.

[12] Lee K, Anastasopoulou C, Chandran C, et al. Thyroid cancer[M]//StatPearls [Internet]. StatPearls Publishing,2023.

[13] Laha D, Nilubol N, Boufraqech M. New therapies for advanced thyroid cancer[J]. Frontiers in endocrinology,2020(11):82.

[14] Konstantinopoulos Panagiotis A, Ursula A Matulonis. Clinical and translational advances in ovarian cancer therapy[J]. Nature cancer,2023,4(9):1239-1257.

[15] Nan Yabing. OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition[J]. Proceedings of the National Academy of Sciences,2024,121(19):e2315348121.